Cleaved-Caspase-1 p20 (D210) rabbit pAb

DETAILS

Isotype: IgG
Category: Antibody
Dilution: WB 1:500-2000, IHC-p 1:50-300, IF 1:50-300
Clonality: Polyclonal
Immunogen: The antiserum was produced against synthesized peptide derived from human Caspase-1. AA range:161-210
Background: This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce 2 subunits, large and small, that dimerize to form the active enzyme. This gene was identified by its ability to proteolytically cleave and activate the inactive precursor of interleukin-1, a cytokine involved in the processes such as inflammation, septic shock, and wound healing. This gene has been shown to induce cell apoptosis and may function in various developmental stages. Studies of a similar gene in mouse suggest a role in the pathogenesis of Huntington disease. Alternative splicing results in transcript variants encoding distinct isoforms. [provided by RefSeq, Mar 2012],
Reactivity: Human;Mouse;Rat
Applications: WB;IF;IHC;ELISA
Concentration: 1 mg/ml
Human Gene Id: 834
Observed Bandkd: 25kD
Alternative Names: CASP1; IL1BC; IL1BCE; Caspase-1; CASP-1; Interleukin-1 beta convertase; IL-1BC; Interleukin-1 beta-converting enzyme; ICE; IL-1 beta-converting enzyme; p45
Storage Stability: -20°C/1 year
Human Swiss Prot No: P29466
Subcellular Location: Cytoplasm . Cell membrane .