RP 001 (hydrochloride)

DESCRIPTION

A potent S1P1 receptor agonist (EC50 = 9 pM); induces internalization and polyubiquitination of S1P1 in a dose-dependent manner; induces dose-dependent lymphopenia in mice (EC50 = 0.03 mg/kg); reduces S1P1-EGFP expression ex vivo on lymphocytes in the isolated lymph node of Edg1eGFP/eGFP mice; inhibits MSS rechallenge-induced enlargement of B cell-rich TLTs and reduces neutrophil accumulation in the airways of a mouse model of experimental hypersensitivity pneumonitis

DETAILS

Inchi: InChI=1S/C24H24N4O4.ClH/c1-14(2)31-21-9-6-15(12-16(21)13-25)24-27-23(28-32-24)19-5-3-4-18-17(19)7-8-20(18)26-11-10-22(29)30;/h3-6,9,12,14,20,26H,7-8,10-11H2,1-2H3,(H,29,30);1H
Purity: ≥98%
Raptas: Product Type|Biochemicals|Receptor Pharmacology|Agonists||Research Area|Cell Biology|Proteolysis|Ubiquitin/Proteasome System||Research Area|Immunology & Inflammation|Adaptive Immunity||Research Area|Immunology & Inflammation|Innate Immunity||Research Area|Lipid Biochemistry|Sphingolipids
Smiles: OC(CCNC1CCC2=C(C3=NOC(C4=CC(C#N)=C(OC(C)C)C=C4)=N3)C=CC=C21)=O.Cl
Inchikey: ZHPGSGYEFGEZAL-UHFFFAOYSA-N
Cas Number: 1781880-34-9
Formulation: A solid
Storage Temp: -20
Shipping Temp: -20
Formula Markup: C24H24N4O4 • HCl
Formula Weight: 468.9
Shelf Life Days: 1460