DESCRIPTION

• Notes: Troubleshooting Guide: Visit bpsbioscience.com/assay-kits-faq for detailed troubleshooting instructions. For further questions, please email support@bpsbioscience.com
• Uniprot: P09237
• Shiptemp: -80°C (dry ice)
• Synonyms: Matrilysin, Matrin, Matrix metalloproteinase-7, MMP-7, Pump-1 protease, Uterine metalloproteinase, MPSL1, PUMP1
• Warnings: Avoid freeze/thaw cycles 
• Category: Protease/Assay Kit
• Background: MMP7 (also known as matrix metalloproteinase 7 or pump-1 protease) is a member of the large family of matrix metalloproteinases (MMP) responsible for the breakdown of extracellular matrix proteins such as casein, collagen, and fibronectin. Most MMPs are secreted as inactive pro-proteins and are activated when cleaved by other extracellular proteinases. MMP7 cleaves fibronectin, gelatin and elastin, but not collagen. MMPs are involved in tissue remodeling and in the escape of metastatic cells from the primary tumor and angiogenesis. MMP7 can activate MMP2 and MMP9, and upregulation of MMP7 is found in many carcinomas. They are candidate therapeutic targets in various diseases related to tissue remodeling including cancer and inflammatory diseases.
• Description: The MMP7 (Matrix MetalloProteinase 7) Fluorogenic Assay Kit is designed to measure MMP7 protease activity for screening and profiling applications, in a homogeneous assay with no time-consuming washing steps. 
• Methodology: Fluorogenic
• Supplied As: The kit contains enough recombinant MMP7, substrate and assay buffer for 100 reactions.
• Unspsc Code: 41105331
• Unspsc Name: Protein chemifluorescent detection reagents or kits or substrates
• Applications: Screen or profile small molecule inhibitors of MMP7.
• Product Type: Assay Kit
• Biosafety Level: Not applicable (BSL-1)
• Related Products: 100552, 79929, 78830
• Contraindications: The final concentration of DMSO in the assay should not exceed 1%.
• Storage Stability: This assay kit will perform optimally for up to 6 months from date of receipt when the materials are stored as directed.
• Scientific Category: Protease