SR324519
PEN2 (PSENEN) Human siRNA Oligo Duplex (Locus ID 55851)
Origene Technologies, Inc.
DESCRIPTION
PSENEN (Human) - 3 unique 27mer siRNA duplexes - 2 nmol each
DETAILS
- Note: Single siRNA duplex (10nmol) can be ordered.
- Purity: HPLC purified
- Refseq: NM_001281532, NM_018468, NM_172341
- Status: 3 Weeks*
- Summary: Presenilins, which are components of the gamma-secretase protein complex, are required for intramembranous processing of some type I transmembrane proteins, such as the Notch proteins and the beta-amyloid precursor protein. Signaling by Notch receptors mediates a wide range of developmental cell fates. Processing of the beta-amyloid precursor protein generates neurotoxic amyloid beta peptides, the major component of senile plaques associated with Alzheimer's disease. This gene encodes a protein that is required for Notch pathway signaling, and for the activity and accumulation of gamma-secretase. Mutations resulting in haploinsufficiency for this gene cause familial acne inversa-2 (ACNINV2). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
- Category: RNAi
- Synonyms: ACNINV2; MDS033; MSTP064; PEN-2; PEN2
- Sequences: Available with shipment
- Stability: One year from date of shipment when stored at -20°C.
- Components: PSENEN (Human) - 3 unique 27mer siRNA duplexes - 2 nmol each (Locus ID 55851)Included - SR30004, Trilencer-27 Universal Scrambled Negative Control siRNA Duplex - 2 nmolIncluded - SR30005, RNAse free siRNA Duplex Resuspension Buffer - 2 ml Need an individual siRNA?
- Uniprot Id: Q9NZ42
- Availability: 3 Weeks
- Quality Control: Tested by ESI-MS
- Performance Guaranteed: OriGene guarantees that at least two of the three Dicer-Substrate duplexes in the kit will provide at least 70% or more knockdown of the target mRNA when used at 10 nM concentration by quantitative RT-PCR when the TYE-563 fluorescent transfection control duplex (cat# SR30002) indicates that >90% of the cells have been transfected and the HPRT positive control (cat# SR30003) provides 90% knockdown efficiency. For non-conforming siRNA, requests for replacement product must be made within ninety (90) days from the date of delivery of the siRNA kit. To arrange for a free replacement with newly designed duplexes, please contact Technical Services at techsupport@origene.com. Please provide your data indicating the transfection efficiency and measurement of gene expression knockdown compared to the scrambled siRNA control (quantitative RT-PCR data required).
- Number of Transfections: Approximately 330 transfections/2nmol in 24-well plate under optimized conditions (final conc. 10 nM).