Human / Cynomolgus Claudin-18.2 Protein, His,Twin-Strep Tag (Nanodisc)

DESCRIPTION

Claudins (CLDNs) are a family of proteins that form tight junctions and maintain the polarity of epithelial and endothelial cells. CLDN18 is specifically expressed in the stomach and lung. Of the two CLDN18 isoform transcripts produced by alternative splicing, CLDN18.2 is a highly selective gastric lineage marker that determines the gastric phenotype in a neoplastic condition, whereas CLDN18.1 is lung specific. CLDN18.2 is a highly selective gastric lineage antigen expressed exclusively on short-lived differentiated gastric epithelial cells where it has only limited accessibility to antibody drugs.14,15 CLDN18.2 is maintained during the course of malignant transformation and thus frequently displayed on the surface of human gastric cancer cells.

DETAILS

Tag: N-10×His & C-Twin-Strep
Host: InsectCells
Size: 100ug
Buffer: 20 mM HEPES, 150 mM NaCl, pH7.5
Format: Liquid
Purity: 80%
Source: Human / Cynomolgus Claudin-18.2, His,Twin-Strep Tag (CL2-H5586) is expressed from Baculovirus-Insect cells. It contains AA Met 1 - Ala 200 (Accession # P56856-2). In the region AA Met 1 - Ala 200, the AA sequence of Human and Cynomolgus Claudin-18.2 are homologus.
Storage: -70℃
Category: Bio-Markers & CD Antigens
Molecule: Claudin-18.2
Conjugate: Unconjugated
Stability: ● The product MUST be stored at -70°C or lower upon receipt; ● -70°C for 3 months under sterile conditions.
Exp Region: Met 1 - Ala 200
Swiss-prot: P56856-2
Package Size: 100ug*1
Characteristics: This protein carries a polyhistidine tag at the N-terminus and a twin strep tag at the C-terminus. The protein has a calculated MW of 26.5 kDa.
Endotoxin Level: 1.0 EU per μg
Molecular Weight: 26.5 kDa
Shipping Condition: Dry ice
Species Reactivity: Human / Cynomolgus
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