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sc-271117 HRP

Scientist.com Supplier

OAS2 (G-9) HRP

Santa Cruz Biotechnology

DESCRIPTION

mouse monoclonal IgG2b; OAS2 Antibody (G-9) is an IgG2b κ mouse monoclonal OAS2 antibody that detects the OAS2 protein of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA. OAS2 Antibody (G-9) is available as both the non-conjugated anti-OAS2 antibody form, as well as multiple conjugated forms of anti-OAS2 antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. The 2'- 5'- oligoadenylate synthetase (OAS) family is comprised of four members: OAS1, OAS2, OAS3 and OASL. These proteins are induced by interferons and function to convert ATP into 2'- 5'- linked oligomers of adenosine in the presence of double-stranded RNA and magnesium ions. Copper, iron and zinc ions strongly inhibit the OAS enzymatic activity, while manganese ions can replace magnesium ions as an activator. The OAS family plays a significant role in the inhibition of cellular protein synthesis as well as in viral infection resistance. OAS2, which represents the "medium form" in the OAS family, contains two OAS1-homologous domains separated by a proline-rich putative linker region. It is functionally active as a dimer. Abnormal expression patterns of OAS2 may be linked to infection flare in Lupus patients.

DETAILS

  • Host: mouse
  • Type: Primary
  • Uniprot: P29728
  • Clonality: Monoclonal
  • Conjugate: HRP
  • Applications: WB, IHC(P), ELISA
  • Human Gene Id: 4939
  • Mouse Gene Id: 246728
  • Protein Target: OAS2
  • Human Gene Name: OAS2
  • Mouse Gene Name: Oas2
  • Species Reactivity: mouse, rat, human