T77520
AOH1996
TargetMol
DESCRIPTION
AOH1996 is an orally active ligand for the replicasome component PCNA (proliferating cell nuclear antigen), targeting the transcription-replication conflict (TRC). It interferes with the interaction of PCNA with its binding proteins, leading to DNA replication stress and apoptosis. AOH1996 causes proteasome-dependent rpb1 degradation and lethal DNA damage by stabilizing the interaction between PCNA and RNA polymerase II, and acts synergistically with DNA damaging agents to inhibit tumor cell growth.
DETAILS
- Cas: 2089314-64-5
- Purity: 98.80%
- Smiles: C(NCC(NC1=C(OC2=CC(OC)=CC=C2)C=CC=C1)=O)(=O)C=3C4=C(C=CC3)C=CC=C4
- Category: Compound
- Molecular Weight: 426.46
- Molecular Formula: C26H22N2O4
Lead Time: < 1 week
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