30-1560
Anti-CD158a/g/h Monoclonal Antibody (Clone:HP-MA4)
Abeomics
DESCRIPTION
Killer cell immunoglobulin-like receptors (KIRs) are polymorphic transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. They are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain (such as CD158a / KIR2DL1) transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain (such as CD158g / KIR2DS5, CD158h / KIR2DS1, or KIR2DS3) lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for CD158 isoforms are subsets of MHC class I molecules.
DETAILS
- Gene: KIR2DL1
- App Id: FACS, IP
- Antigen: CD158a/g/h
- Gene Id: 3802
- Isotype: Mouse IgG2b
- Format Id: Purified
- Clone Name: HP-MA4
- Uniprot Id: P43626
- Host Animal: Mouse
- Clonality Id: Monoclonal
- Purification: Purified by protein-A affinity chromatography
- Reactivity Id: Human
- Alternative Name: KIR2DL1||CD158A||NKAT1
- Storage Condition: Store at 2-8°C. Do not freeze.
- Immunogen Information: Human NK cell line LB2
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