mouse monoclonal IgG1; Dynein HC Antibody (C-5) is an IgG1 κ mouse monoclonal Dynein HC antibody (also designated dynein cytoplasmic 1 heavy chain 1 antibody, p22 antibody, DHC1 antibody, DNCL antibody, DYHC antibody, HL-3 antibody, CMT2O antibody, DHC1a antibody, DNCH1 antibody, DNECL antibody, Dnchc1 antibody, Spinal Muscular Atrophy, Lower Extremity Dominant (SMA-LED) antibody, or SMALED1 antibody) that detects the Dynein HC protein of mouse, rat and human origin by WB, IP, IF and ELISA. Dynein HC Antibody (C-5) is available as both the non-conjugated anti-Dynein HC antibody form, as well as multiple conjugated forms of anti-Dynein HC antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. Dyneins are multisubunit, high molecular weight ATPases that interact with microtubules to generate force by converting the chemical energy of ATP into the mechanical energy of movement. Cytoplasmic or axonemal Dynein heavy, intermediate, light and light-intermediate chains are all components of minus end-directed motors; the complex transports cellular cargos towards the central region of the cell. Axonemal Dynein motors contain one to three non-identical heavy chains and cause a sliding of microtubules in the axonemes of cilia and flagella in a mechanism necessary for cilia to beat and propel the cell. Cytoplasmic Dynein is an approximately 12 subunit complex of two heavy chains, two intermediate chains to anchor Dynein to its cargo, four smaller intermediate chains and several light chains. It performs functions necessary for cell survival such as organelle transport and centrosome assembly. The carboxy terminus of Dynein is important for microtubule-dependent motility and is highly conserved, while the amino terminal regions are more variable. Several proteins regulate Dynein activity, including dynactin, LIS1 and NudEL(NudE-like).

Free sample available. Limit 3 free samples for each full size Santa Cruz Biotechnology primary antibody ordered. All samples must be different. Customer responsible for shipping costs.