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E6672Hu

Human B-cell Antigen Receptor Complex-associated Protein Alpha Chain, CD79A ELISA Kit

Bioassay Technology Laboratory

DESCRIPTION

Required in cooperation with CD79B for initiation of the signal transduction cascade activated by binding of antigen to the B-cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late endosomes and antigen presentation. Also required for BCR surface expression and for efficient differentiation of pro- and pre-B-cells. Stimulates SYK autophosphorylation and activation. Binds to BLNK, bringing BLNK into proximity with SYK and allowing SYK to phosphorylate BLNK. Also interacts with and increases activity of some Src-family tyrosine kinases. Represses BCR signaling during development of immature B-cells.

DETAILS

  • Gene Id: 973
  • Uniprot: P11912
  • Lead Time: 3 days
  • Assay Type: Sandwich
  • Sample Type: Serum, plasma, cell culture supernates
  • Sensitivity: 9.99ng/L
  • Detection Range: 20-3800ng/L
  • Detection Method: ELISA
  • Species Reactivity: Human