sc-374528 SAMPLE sc-374528
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API5 (E-12)
Santa Cruz Biotechnology
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DESCRIPTION
mouse monoclonal IgG2b; API5 Antibody (E-12) is an IgG1 κ mouse monoclonal API5 antibody (also designated API5 antibody) that detects the API5 protein of mouse, rat and human origin by WB, IP, IF and ELISA. API5 Antibody (E-12) is available as both the non-conjugated anti-API5 antibody form, as well as multiple conjugated forms of anti-API5 antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. API5 (apoptosis inhibitor 5), also known as AAC11 (antiapoptosis clone 11 protein), FIF (fibroblast growth factor 2-interacting factor), MIG8, XAGL or API5L1, is a widely expressed antiapoptotic nuclear protein that is highly conserved from flies to humans. API5 contains a nuclear localization sequence, an LxxLL motif, a leucine zipper domain and a transactivation domain flanked by two acidic domains. API5 forms a nuclear localized complex with FGF-2 and may mediate FGF-2-dependent signaling. API5 is believed to function as a transcription regulator and is able to regulate the synthesis of MMP-2 (matrix metalloproteinase-2). In addition, API5 is known to specifically suppress E2F-dependent apoptosis. It is expressed in a variety of cancer cell lines and its expression is linked to tumor progression and the degree of malignancy.
DETAILS
- Host: mouse
- Type: Primary
- Uniprot: Q9BZZ5
- Clonality: Monoclonal
- Conjugate: unconjugated
- Applications: WB, IP, IF, ELISA
- Human Gene Id: 8539
- Mouse Gene Id: 11800
- Protein Target: API5
- Human Gene Name: API5
- Mouse Gene Name: Api5
- Species Reactivity: mouse, rat, human
PROMOTION TERMS
Free sample available. Limit 3 free samples for each full size Santa Cruz Biotechnology primary antibody ordered. All samples must be different. Customer responsible for shipping costs.
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