PRNP Antibody (Center) Blocking Peptide

DETAILS

Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
Gene Id: 5621
Category: Peptides; Blocking Peptides
Subtitle: Synthetic peptide
Gene Name: PRNP
Other Names: Major prion protein, PrP, ASCR, PrP27-30, PrP33-35C, CD230, PRNP, ALTPRP, PRIP, PRP
Availability: 2 weeks
Bio Background: PRNP is a membrane glycosylphosphatidylinositol-anchored glycoprotein that tends to aggregate into rod-like structures. This protein contains a highly unstable region of five tandem octapeptide repeats. Mutations in the repeat region as well as elsewhere in PRNP gene have been associated with Creutzfeldt-Jakob disease, fatal familial insomnia, Gerstmann-Straussler disease, Huntington disease-like 1, and kuru.
Bio References: Cervenakova L., Buetefisch C., Lee H.S., Taller I., Stone G., Gibbs C.J. Jr., Brown P., Hallett M., Goldfarb L.G.Am. J. Med. Genet. 88:653-656(1999) Perry R.T., Go R.C., Harrell L.E., Acton R.T.Am. J. Med. Genet. 60:12-18(1995)NMR structures of three single-residue variants of the human prion protein.Proc. Natl. Acad. Sci. U.S.A. 97:8340-8345(2000)
Primary Accession: P04156
Targetspecificity: The synthetic peptide sequence used to generate the antibody AP2865c was selected from the Center region of human PRNP. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.