mouse monoclonal IgG1; Cas-L Antibody (2G9) is an IgG1 κ mouse monoclonal Cas-L antibody (also designated Cas-L antibody) that detects the Cas-L protein of mouse, rat and human origin by WB, IP and IF. Cas-L Antibody (2G9) is available as both the non-conjugated anti-Cas-L antibody form, as well as multiple conjugated forms of anti-Cas-L antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. Cas family proteins are adhesion docking molecules that mediate protein-protein interactions and contribute to a number of signal transduction pathways. Cas-L (also designated human enhancer of filamentation (HEF1) and neural precursor cell expressed, developmentally down-regulated 9 (NEDD9), participates in integrin and growth factor signaling pathways that regulate growth, motility and apoptosis. Cas-L consists of two isoforms, p105 and p115. The larger molecular weight form is a result of Ser/Thr phosphorylation. Cas-L phosphorylation is dependent on cell adhesion and Src kinase activity. Cas-L acts as a downstream effector of FAK in the invasive behavior of glioblastoma cells. TGFβ1 regulates Cas-L gene expression and influences phosphorylation. Adhesion-dependent Actin organization regulates proteasomal turnover of Cas-L through the activity of PP2A. Tyrosine phosphorylated Cas-L can bind FAK in dendrite and soma of neurons after ischemia. Cas-L can promote neurite outgrowth of PC-12 cells.

Free sample available. Limit 3 free samples for each full size Santa Cruz Biotechnology primary antibody ordered. All samples must be different. Customer responsible for shipping costs.