3α,5α-THDOC

DESCRIPTION

A neurosteroid and positive allosteric modulator of GABAA receptors; inhibits binding of TBPS and increases binding of flunitrazepam to rat synaptosomal membrane preparations in a concentration-dependent manner; potentiates GABA-induced chloride currents in cultured rat hippocampal and spinal cord neurons; inhibits seizures induced by pilocarpine or PTZ in mice (ED50s = 7.3 and 15 mg/kg, respectively); increases the number of entries into and percentage of time spent in the open arms of the elevated plus maze in mice at 20 mg/kg

DETAILS

Inchi: InChI=1S/C21H34O3/c1-20-9-7-14(23)11-13(20)3-4-15-16-5-6-18(19(24)12-22)21(16,2)10-8-17(15)20/h13-18,22-23H,3-12H2,1-2H3/t13-,14+,15-,16-,17-,18+,20-,21-/m0/s1
Purity: ≥95%
Raptas: Product Type|Biochemicals|Ion Channel Modulation|Activators||Product Type|Biochemicals|Lipids|Sterol Lipids||Research Area|Neuroscience|Behavioral Neuroscience|Anxiety||Research Area|Neuroscience|Neuroendocrinology||Research Area|Neuroscience|Seizure Disorders
Smiles: C[C@@]12[C@](CC[C@@H]2C(CO)=O)([H])[C@]3([H])CC[C@@]4([H])C[C@H](O)CC[C@]4(C)[C@@]3([H])CC1
Inchikey: CYKYBWRSLLXBOW-GDYGHMJCSA-N
Cas Number: 567-02-2
Formulation: A solid
Storage Temp: -20
Shipping Temp: -20
Formula Markup: C21H34O3
Formula Weight: 334.5
Shelf Life Days: 1460