5142342-100mg 5142342-50mg
3-Methyladenine
Biogems
DESCRIPTION
3-Methyladenine is a phosphatidylinositol 3-kinase (PI3k) inhibitor, blocking class I, class II, and class III PI3ks. This small molecule is reported to inhibit autophagy and apoptosis. The ability of 3-methyladenine to suppress the formation of electron microscopically visible autophagosomes suggests that it may be regarded as a specific inhibitor of autophagy.
DETAILS
- Purity: ≥98%
- Synonyms: 3-MA, N(3)-methyladenine
- Cas Number: 5142-23-4
- References: Seglen, P. O., & Gordon, P. B. (1982). 3-Methyladenine: specific inhibitor of autophagic/lysosomal protein degradation in isolated rat hepatocytes.Proceedings of the National Academy of Sciences, 79(6), 1889-1892. Wu, Y. T., Tan, H. L., Shui, G., Bauvy, C., Huang, Q., Wenk, M. R., ... & Shen, H. M. (2010). Dual role of 3-methyladenine in modulation of autophagy via different temporal patterns of inhibition on class I and III phosphoinositide 3-kinase. Journal of Biological Chemistry, 285(14), 10850-10861. CARO, L. H. P., PLOMP, P. J., WOLVETANG, E. J., KERKHOF, C., & MEIJER, A. J. (1988). 3‐Methyladenine, an inhibitor of autophagy, has multiple effects on metabolism. European Journal of Biochemistry, 175(2), 325-329.
- Application: FA
- Formulation: Crystalline solid
- Chemical Name: 3-methylpurin-6-amine
- Molecular Weight: 149.2
- Molecular Formula: C6H7N5
- Storage Conditions: Product should be kept at -20°C.
- Pubchem Openeye Can Smiles: CN1C=NC(=N)C2=C1N=CN2