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28830

BV6

Cayman Chemical

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DETAILS

  • Inchi: InChI=1S/C70H96N10O8/c1-47(71-3)63(81)75-59(53-37-21-11-22-38-53)69(87)79-45-27-41-55(79)65(83)77-61(57(49-29-13-7-14-30-49)50-31-15-8-16-32-50)67(85)73-43-25-5-6-26-44-74-68(86)62(58(51-33-17-9-18-34-51)52-35-19-10-20-36-52)78-66(84)56-42-28-46-80(56)70(88)60(54-39-23-12-24-40-54)76-64(82)48(2)72-4/h7-10,13-20,29-36,47-48,53-62,71-72H,5-6,11-12,21-28,37-46H2,1-4H3,(H,73,85)(H,74,86)(H,75,81)(H,76,82)(H,77,83)(H,78,84)/t47-,48-,55-,56-,59-,60-,61-,62-/m0/s1
  • Purity: ≥98%
  • Raptas: Product Type|Biochemicals||Research Area|Cancer|Cell Death|Apoptosis||Research Area|Cancer|Cell Signaling|NF-κB Signaling||Research Area|Cancer|Transcription Factors|NF-κB
  • Smiles: O=C(N[C@@H](C(C1=CC=CC=C1)C2=CC=CC=C2)C(NCCCCCCNC([C@H](C(C3=CC=CC=C3)C4=CC=CC=C4)NC([C@@H]5CCCN5C([C@H](C6CCCCC6)NC([C@@H](NC)C)=O)=O)=O)=O)=O)[C@@H]7CCCN7C([C@H](C8CCCCC8)NC([C@@H](NC)C)=O)=O
  • Inchikey: DPXJXGNXKOVBJV-YLOPQIBLSA-N
  • Cas Number: 1001600-56-1
  • Formulation: A crystalline solid
  • Storage Temp: -20
  • Shipping Temp: -20
  • Formula Markup: C70H96N10O8
  • Formula Weight: 1205.6
  • Shelf Life Days: 1460

DESCRIPTION

A bivalent Smac mimetic and IAP antagonist; binds to IAP1 and XIAP (Kds = 0.46 and 1.3 nM, respectively); induces autoubiquitination and proteasomal degradation of IAP1 and XIAP in MDA-MB-231 cells at 5 μM; induces NF-κB activation and TNF-dependent apoptosis in A2058 and MDA-MB-231 cells at 4 μM; enhances radiosensitization and increases apoptosis in HCC193 and H460 NSCLC cell lines; induces cell death in a panel of 40 primary, patient-derived BCP-ALL samples at 1 μM; increases survival and time to relapse in a high-risk BCP-ALL PDX mouse model