Monoclonal Antibody to Desmoglein 3 (Clone: ABM4A31)

DESCRIPTION

DSG3 (Desmoglein 3) is a calcium-binding transmembrane glycoprotein component of desmosomes, conferring strong cell-cell adhesion. Desmosomes are button-like points of intercellular contact that allow the attachment of cytoskeletal elements to the plasma membrane at sites of cell-cell adhesion. DSG3 is expressed in basal and immediate suprabasal layers of skin. To maintain cell-cell adhesion DSG3 interacts with other desmosomal proteins, such as plakoglobin. Plakoglobin is closely related to Beta-catenin, which is a well-known downstream effector molecule in the canonical Wnt signaling pathway.DSG3 also promotes cancer cell growth and invasion through a plakoglobin-mediated signaling pathway.

DETAILS

Gene: DSG3
App Id: IHC
Antigen: Desmoglein 3
Gene Id: 1830
Isotype: Mouse IgG2b Kappa
Format Id: Purified
Clone Name: ABM4A31
Uniprot Id: P32926
Host Animal: Mouse
Clonality Id: Monoclonal
Purification: Protein G Chromatography
Reactivity Id: Human
Product Content: 25 µg in 50 µl/100 µg in 200 µl PBS containing 0.05% BSA and 0.05% sodium azide. Sodium azide is highly toxic.
Alternative Name: DSG3||CDHF6
Application Note: Immunohistochemical analysis: 1 µg/ml
Storage Condition: Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.
Immunogen Information: A partial length recombinant Desmoglein 3 protein (amino acids 328-526) was used as the immunogen for this antibody.