30678
Cipargamin
Cayman Chemical
DESCRIPTION
An antimalarial agent; inhibits the Na+-ATPase activity of wild-type or mutant PfATP4 (IC50s = 12.3-13.9 and 21.1-32.5 nM, respectively, in P. falciparum membranes); active against the P. falciparum chloroquine-sensitive strain NF54 and chloroquine-resistant strain K1 (IC50s = 0.5 and 0.6 nM, respectively); reduces parasitemia and increases survival in a mouse model of P. berghei infection at 10, 30, and 100 mg/kg
DETAILS
- Inchi: InChI=1S/C19H14Cl2FN3O/c1-8-4-11-10-6-14(22)13(21)7-16(10)23-17(11)19(25-8)12-5-9(20)2-3-15(12)24-18(19)26/h2-3,5-8,23,25H,4H2,1H3,(H,24,26)/t8-,19+/m0/s1
- Purity: ≥98%
- Raptas: Product Type|Biochemicals|Antiparasitics|Antiprotozoals||Product Type|Biochemicals|Small Molecule Inhibitors|ATPases||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Parasitic Diseases|Malaria
- Smiles: FC1=C(C=C(C2=C1)NC3=C2C[C@@H](N[C@]34C5=C(NC4=O)C=CC(Cl)=C5)C)Cl
- Inchikey: CKLPLPZSUQEDRT-WPCRTTGESA-N
- Cas Number: 1193314-23-6
- Formulation: A crystalline solid
- Storage Temp: -20
- Shipping Temp: -20
- Formula Markup: C19H14Cl2FN3O
- Formula Weight: 390.2
- Shelf Life Days: 1460