Anti-NKX3.1 (Metastatic Prostate Adenocarcinoma Marker) Monoclonal Antibody(Clone: NKX3.1/3348)

DESCRIPTION

NKX3.1 is a prostate specific gene encoding a transcription factor that plays an important role in normal prostate development and carcinogenesis. It is a prostatic tumor suppressor gene located on chromosome 8p21.2, which frequently undergoes a loss of heterozygosity. NKX3.1 expression is highly restricted in prostate epithelial cells and therefore can be used as a diagnostic biomarker for prostate cancer and other metastatic lesions of prostatic origin. Furthermore, NKX3.1 shows better sensitivity than Prostate Specific Antigen (PSA) for identifying metastatic prostatic adenocarcinoma. This sµggests that immunohistochemical staining of NKX3.1, along with other prostate-restricted markers, may be valuable for the definitive determination of prostatic origin in poorly differentiated metastatic carcinomas.

DETAILS

Gene: NKX3-1
App Id: ELISA,IHC
Gene Id: 4824
Isotype: Mouse IgG2b, kappa
Clone Name: NKX3.1/3348
Uniprot Id: Q99801
Host Animal: Mouse
Clonality Id: Monoclonal
Reactivity Id: Human
Product Content: 200 µg/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with0.05% BSA & 0.05% azide. Also available WITHOUT BSA &azide at 1.0mg/ml.
Alternative Name: NK3 Transcription Factor Related, Locus 1; NK Homeobox (Drosophila), Family 3, A; NK3 Transcription Factor Homolog A; NK Homeobox, Family 3, A; Homeobox Protein Nkx-3.1; BAPX2; NKX3
Application Note: ELISA (For coating, order Ab without BSA);,Immunohistochemistry (Formalin-fixed) (1-2ug/ml for 30 minutes at RT),(Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95&degC followed by cooling at RT for 20 minutes);
Storage Condition: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous.
Immunogen Information: Recombinantfragment(around aa 92-224) of humanNKX3.1 protein (exact sequence is proprietary)