mouse monoclonal IgG2b; GABA T-3 Antibody (G-6) is an IgG2b κ mouse monoclonal GABA T-3 antibody (also designated GABA T-3 antibody) that detects the GABA T-3 protein of mouse and rat origin by WB, IP, IF, IHC(P) and ELISA. GABA T-3 Antibody (G-6) is available as both the non-conjugated anti-GABA T-3 antibody form, as well as multiple conjugated forms of anti-GABA T-3 antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. As Glutamate decarboxylases, GAD-65 and GAD-67 function to catalyze the production of GABA (gamma-aminobutyric acid). In the central nervous system, GABA functions as the main inhibitory transmitter by increasing the chlorine conductance that inhibits neuronal firing. GABA has been shown to activate both ionotropic (GABAA) and metabotropic (GABAB) receptors, as well as a third class of receptors called GABAC. Both GABAA and GABAC are ligand-gated ion channels, however, they are structurally and functionally distinct. GABA transporters have also been identified and include GABA T-1, GABA T-2 and GABA T-3 (also designated GAT-1, -2, and -3). GABA T-3 is a 632 amino acid membrane protein that is expressed in brain, specifically in glial cells. The GABA transporters function to terminate GABA action by actively pumping GABA back into presynaptic terminals.

Free sample available. Limit 3 free samples for each full size Santa Cruz Biotechnology primary antibody ordered. All samples must be different. Customer responsible for shipping costs.