1004515-50mg 1004515-10mg
1-EBIO
Biogems
DESCRIPTION
1-EBIO is an epithelial Ca2+-activated K+ and CFTR channel activator. It is reported to enhance the differentiation of embryonic stem cells into cardiomyocytes.
DETAILS
- Purity: ≥98%
- Synonyms: 1-ethyl-2-benzimidazolinone, 1-Ethylbenzimidazolinone, 1-EB10
- Cas Number: 10045-45-1
- References: 1.Anderson, N. J., Slough, S., & Watson, W. P. (2006). In vivo characterisation of the small-conductance KCa (SK) channel activator 1-ethyl-2-benzimidazolinone (1-EBIO) as a potential anticonvulsant. European journal of pharmacology, 546(1-3), 48-53. 2.Walker, S. D., Doras, K. A., Ings, N. T., Crane, G. J., & Garland, C. J. (2001). Activation of endothelial cell IKCa with 1‐ethyl‐2‐benzimidazolinone evokes smooth muscle hyperpolarization in rat isolated mesenteric artery. British journal of pharmacology, 134(7), 1548-1554. 3.Müller, M., Stockmann, M., Malan, D., Wolheim, A., Tischendorf, M., Linta, L., ... & Wobus, A. M. (2012). Ca2+ activated K channels-new tools to induce cardiac commitment from pluripotent stem cells in mice and men. Stem Cell Reviews and Reports, 8(3), 720-740.
- Application: FA
- Formulation: Crystalline solid
- Chemical Name: 3-ethyl-1H-benzimidazol-2-one
- Molecular Weight: 162.2
- Molecular Formula: C9H10N2O
- Storage Conditions: Product should be kept at -20°C.
- Pubchem Openeye Can Smiles: CCN1C2=CC=CC=C2NC1=O