DESCRIPTION

• Aa: 1-21
• Mw: 2091.5 Da
• Tags: none
• Format: aqueous solution
• Purity: ≥95% by HPLC
• Genbank: NM_003548
• Uniprot: P62805
• Shiptemp: -20°C or -80°C
• Synonyms: H4, HIST4, Histone h4
• Warnings: Avoid freeze/thaw cycles.
• Category: Methyltransferase/Substrates
• Background: Histone acetyltransferase (HAT) p300/CBP catalyses the acetylation of this N-terminal tail of free histone H4 at Lys5, 8, 12, 16. Lys8 is thought to be the preferred acetylation site in H4. A number of methyltransferases also modify this region of the histone.
• References: Application Reference(s): 1. Differential mode of antimicrobial actions of arginine-rich and lysine-rich histones against Gram-positive Staphylococcus aureus (2013) 2. Extracellular histones are essential effectors of C5aR- and C5L2-mediated tissue damage and inflammation in acute lung injury (2013)
• Description: A peptide substrate for Histone 4 R3 methyltransferases. The peptide corresponds to amino acid residues 1-21 of histone H4.
• Supplied As: 800 µM solution in water (200 µl)
• Unspsc Code: 41105332
• Unspsc Name: Protein chemiluminescent detection reagents or kits or substrates
• Applications: Useful as a substrate for histone methyltransferase (at R3) and acetyltransferase (at K5, K8, K12 and K16) family assays and for screening small molecular inhibitors of Histone 4 (R3) methyltransferases for drug discovery.
• Product Type: Substrate
• Biosafety Level: Not applicable (BSL-1)
• Storage Stability: ≥ 12 months at -20°C or -70°C
• Amino Acid Sequence: SGRGKGGKGLGKGGAKRHRKV
• Scientific Category: Methyltransferase