B0084-258924
XL147
BOC Sciences
DETAILS
- Smiles: CC1=CC=C(C=C1)S(=O)(=O)NC2=NC3=CC=CC=C3N=C2NC4=CC5=NSN=C5C=C4
- Aliases: XL147-II; XL147 II; XL147II; XL147 derivative II; XL147derivativeII; XL147-derivative-II; N-[3-(2,1,3-Benzothiadiazol-5-ylamino)-2-quinoxalinyl]-4-methylbenzenesulfonamide;SAR245408;N-[3-(Benzo[c][1,2,5]thiadiazol-5-ylaMino)quinoxalin-2-yl]-4-MethylbenzenesulfonaMide;PI3K inhibitorX
- Cas Number: 956958-53-5
- Molecular Weight: 448.52
- Molecular Formula: C21H16N6O2S2
DESCRIPTION
Pilaralisib is a Class 1 phosphatidylinositol 3 kinase (PI3K) family inhibitor. It is an orally bioavailable small molecule, targeting the class I PI3K family of lipid kinases. It is a pyrimidine derivatives compound discovered by Exelixis Inc. It has potential antineoplastic activity. It binds to class 1 PI3Ks in an ATP-competitive manner by inhibiting the production of the secondary messenger phosphatidylinositol-3,4,5-trisphosphate (PIP3) and inhibiting the activation of the PI3K signaling pathway.