Human Integrin alpha 4 beta 7 (ITGA4&ITGB7) Heterodimer Protein, His Tag&Tag Free (MALS verified)

DESCRIPTION

Integrin alpha 4 beta 7 is an integrin family adhesion receptor that shares subunits with alpha 4 beta 1 (VLA4) and the E-Cadherin receptor, alpha E beta 7 . Integrin alpha 4 beta 7, which is critical for homing to intestinal mucosa, is induced during T cell activation in Peyer’s patches or mesenteric lymph nodes.Its expression requires signals from local dendritic and stromal cells, including secreted retinoic acid. The HIV-1 envelope protein gp120 binds to the active form of Integrin alpha 4 beta 7, and this may or may not account for the concentration of HIV-1 virus in the gut-associated lymphoid tissue (GALT). Integrin alpha 4 beta 7 may also be involved in lymphocyte trafficking in acute intestinal graft vs. host disease (GVHD).

DETAILS

Tag: C-6×His | Native
Host: HEK293
Size: 1mg
Buffer: 50 mM Tris, 150 mM NaCl, pH8.0
Format: Powder
Purity: 90%
Source: Human ITGA4&ITGB7 Heterodimer Protein, His Tag&Tag Free (IT7-H52W5) is expressed from human 293 cells (HEK293). It contains AA Tyr 34 - Arg 620 & Glu 20 - Pro 521 (Accession # P13612-1 & P26010-1).
Storage: -20℃
Category: Bio-Markers & CD Antigens
Molecule: Integrin alpha 4 beta 7
Conjugate: Unconjugated
Stability: ● -20°C to -70°C for 12 months in lyophilized state; ● -70°C for 3 months under sterile conditions after reconstitution. For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Exp Region: Tyr 34 - Arg 620 & Glu 20 - Pro 521
Swiss-prot: P13612-1 | P26010-1
Package Size: 200ug*5
Characteristics: Human ITGA4&ITGB7 Heterodimer Protein, His Tag&Tag Free, produced by co-expression of ITGA4 and ITGB7, has a calculated MW of 59.5 kDa (ITGA4) & 59.4 kDa (ITGB7). The protein migrates as 75-95 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.
Endotoxin Level: 1.0 EU per μg
Molecular Weight: 59.5 kDa & 59.4 kDa
Shipping Condition: RT
Species Reactivity: Human
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