[KO Validated] PARP1 Rabbit pAb

DESCRIPTION

PARP1 is a poly-ADP-ribosyltransferase that mediates poly-ADP-ribosylation of proteins and plays a key role in DNA repair. It is involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks.

DETAILS

Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Isotype: IgG
Storage: Store at -20℃. Avoid freeze / thaw cycles.
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 81-390 of human PARP1.
Reactivity: Human, Mouse, Rat
References: 1. Alkhatib H, et al. (1987) Proc Nat Acad Sci 84, 1224-1228.2. Yu SW, et al. (2002) Science 297, 259-263.
Swiss Prot: P09874
Detected Mw: 89KDa/113KDa
Applications: WB (1:1000 - 1:3,000) IHC (1:50 - 1:200) IF (1:50 - 1:200) IP (not tested) Note: Antibody dilution should be optimized by users.
Availability: In stock
Host Species: Rabbit
Purification: Protein A or G affinity purification
Also Known As: ADPRT;ADPRT 1;ADPRT1;ARTD1;PARP;PARP-1;PPOL;pADPRT-1;PARP1;CleavedPARP;PARP1
Calculated Mw: 113kDa
Concentration: See labels on tube
Shipping Method: Wet ice shipping