B2693-194471
PF-562271
BOC Sciences
DETAILS
- Smiles: CN(C1=C(C=CC=N1)CNC2=NC(=NC=C2C(F)(F)F)NC3=CC4=C(C=C3)NC(=O)C4)S(=O)(=O)C
- Aliases: PF-562271; PF 562271; PF562271
- Cas Number: 717907-75-0
- Molecular Weight: 507.49
- Molecular Formula: C21H20F3N7O3S
DESCRIPTION
PF-562271 is a potent, ATP-competitive, reversible inhibitor of FAK with IC50 of 1.5 nM, ~10-fold less potent for Pyk2 than FAK and >100-fold selectivity against other protein kinases, except for some CDKs.