Cynomolgus Integrin alpha E beta 7 (ITGAE&ITGB7) Heterodimer Protein, His Tag&Tag Free

DESCRIPTION

Integrin alpha E beta 7 consist of two major subunits: Integrin alpha E (ITGAE) also known as CD103 (cluster of differentiation 103) and Integrin beta-7 is an integrin protein that in humans is encoded by the ITGB7 gene. Integrin alpha E beta 7 (CD103) is expressed mainly by cells of the T lymphocyte lineage within mucosal tissues. This is a strikingly narrow pattern of expression compared with that of other integrins. Lymphocytes expressing alpha E beta 7 are abundant in the gut and comprise a major part of the total T cell complement of the body. The effectiveness of lung transplantation is marred by the relatively high incidence of rejection. The lung normally contains a large population of lymphocytes in contact with the airway epithelium, a proportion of which expresses the mucosal integrin, alpha(E)(CD103)beta(7). This integrin is not a homing receptor, but is thought to retain lymphocytes at the epithelial surface.

DETAILS

Tag: C-10×His | Native
Host: HEK293
Size: 1mg
Buffer: 50 mM Tris, 150 mM NaCl, pH7.5
Format: Powder
Purity: 90%
Source: Cynomolgus ITGAE&ITGB7 Heterodimer Protein, His Tag&Tag Free (IT7-C52W3) is expressed from human 293 cells (HEK293). It contains AA Phe 38 - Ser 1142 & Glu 20 - His 723 (Accession # XP_045231543.1 & XP_005571028.2).
Storage: -20℃
Category: Bio-Markers & CD Antigens
Molecule: Integrin alpha E beta 7
Conjugate: Unconjugated
Stability: ● -20°C to -70°C for 12 months in lyophilized state; ● -70°C for 3 months under sterile conditions after reconstitution. For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Exp Region: Phe 38 - Ser 1142 & Glu 20 - His 723
Swiss-prot: XP_045231543.1 | XP_005571028.2
Package Size: 1mg*1
Characteristics: Cynomolgus ITGAE&ITGB7 Heterodimer Protein, His Tag&Tag Free, produced by co-expression of ITGAE and ITGB7, has a calculated MW of 128.3 kDa (ITGAE) and 81.6 kDa (ITGB7). The protein migrates as 95-110 kDa and 140-160 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under non-reducing (NR) condition (SDS-PAGE) due to glycosylation.
Endotoxin Level: 1.0 EU per μg
Molecular Weight: 128.3 kDa & 81.6 kDa
Shipping Condition: RT
Species Reactivity: Cynomolgus
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