DESCRIPTION

• Form: Antigen Affinity Purified from Pooled Serum
• Gene: GABRA4
• Host: Rabbit
• Rrid: AB_2800407
• Type: Primary Antibody
• Buffer: 10 mM HEPES (pH 7.5), 150 mM NaCl, 100 µg per ml BSA and 50% glycerol.
• Target: GABAA Receptor α4
• Isotype: IgG
• Storage: Storage at -20°C is recommended, as aliquots may be taken without freeze/thawing due to presence of 50% glycerol. Stable for at least 1 year at -20°C.
• Shipping: Blue Ice
• Synonyms: GABA(A) receptor subunit alphα4 antibody, GABA(A) receptor subunit alpha-4 antibody, GABR A4 antibody, GABRα4 antibodyGabra4 antibody, Gamma aminobutyric acid (GABA) A receptor alphα4 antibody, Gamma aminobutyric acid A receptor alphα4 antibody, Gamma aminobutyric acid receptor alphα4 subunit antibody, Gamma aminobutyric acid receptor subunit alphα4 antibody, Gamma-aminobutyric acid receptor subunit alpha-4 antibody, GBRA4_HUMAN antibody
• Clonality: Polyclonal
• Immunogen: Fusion protein from the cytoplasmic loop of the α4 subunit of rat GABAA receptor.
• Expiration: After date of receipt, stable for at least 1 year at -20°C.
• Specificity: Specific for endogenous levels of the ~ 64 kDa α4-subunit of the GABAA receptor.
• Applications: WB, IHC
• Ncbi Gene Id: 140675
• Conjugate Exem: Unconjugated
• Physical State: Liquid
• Quality Control: Western blots performed on each lot.
• Usage Statement: For research use only. Not intended for therapeutic or diagnostic use. Use of all products is subject to our terms and conditions, which can be viewed on our website.
• Molecular Weight: 64
• Production Notes: Prepared from pooled rabbit serum by affinity purification using a column to which the fusion protein immunogen was coupled.
• Dilution Range Wb: 1:1000
• Immunogen Species: Rat
• Dilution Range Ihc: 1:300
• Species Reactivity: Mouse and Rat
• Target Description: Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system, causing a hyperpolarization of the membrane through the opening of a Cl− channel associated with the GABA-A receptor (GABA-A-R) subtype. GABA-A-Rs are important therapeutic targets for a range of sedative, anxiolytic, and hypnotic agents and are implicated in several diseases including epilepsy, anxiety, depression, and substance abuse. The GABA-A-R is a multimeric subunit complex. To date six αs, four βs and four γs, plus alternative splicing variants of some of these subunits, have been identified (Olsen and Tobin, 1990; Whiting et al., 1999; Ogris et al., 2004). Injection in oocytes or mammalian cell lines of cRNA coding for α- and β-subunitsresults in the expression of functional GABA-A-Rs sensitive to GABA. However, coexpression of a γ-subunit is required for benzodiazepine modulation. The various effects of the benzodiazepines in brain may also be mediated via different α-subunits of the receptor (McKernan et al., 2000; Mehta and Ticku, 1998; Ogris et al., 2004; Pöltl et al., 2003).
• Dilution Range Wb Brain: 1:1000
• Uniprot Number Immunogen Species: P28471

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