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Recombinant Human MANF



  • Gene Id: 7873
  • Uniprot: P55145
  • Activity: Determined by its ability to stimulate the proliferation of rat C6 cells. The expected ED50 for this effect is 15-25 ug/ml.
  • Category: RUO Cytokines
  • Subcategory: Neurotrophins
  • Research Areas: Angiogenesis/Cardiovascular, Neurobiology, Stem Cells and Differentiation
  • Alternative Names: Mesencephalic Astrocyte-derived Neurotrophic Factor, ARMET, Arginine-rich protein (ARP)
  • Species of Origin: Human
  • Expression System Source: E.coli


MANF is a secreted neurotrophic factor that is expressed in brain, neuronal and certain non-neuronal tissues. It has been shown to promote the survival, growth and function of dopamine-specific neurons. MANF and its structural homolog CDNF each contain a N-terminal, saposin-like, lipid-binding domain, and a carboxyl-terminal domain that is not homologous to previously characterized protein structures. MANF and CDNF can prevent 6-OHDA-induced degeneration of dopaminergic neurons by triggering survival pathways in a rat experimental model of Parkinson's disease. Recombinant Human MANF is an 18.1 kDa protein consisting of 158 amino acids, including 8 cysteine residues.