JNJ-10181457 (hydrochloride)

DESCRIPTION

A histamine H3 receptor antagonist (Kis = 1.17 and 7.08 nM for human and rat receptors, respectively); increases extracellular norepinephrine and acetylcholine levels in the frontal cortex of rats at 10 mg/kg; reduces the number of cataplectic attacks and time spent in cataplexy in familial narcoleptic Dobermans at 1.25-10 mg/kg; decreases the time spent in the open areas of the elevated zero maze in mice at 10 mg/kg, as well as increases locomotor activity in an open field test; inhibits LPS-induced increases in time spent immobile in the tail suspension test in mice.

DETAILS

Inchi: InChI=1S/C20H28N2O/c1-3-10-21(11-4-1)12-5-2-7-19-8-6-9-20(17-19)18-22-13-15-23-16-14-22/h6,8-9,17H,1,3-5,10-16,18H2
Purity: ≥98%
Raptas: Product Type|Biochemicals|Receptor Pharmacology|Antagonists||Research Area|Neuroscience|Behavioral Neuroscience|Anxiety||Research Area|Neuroscience|Behavioral Neuroscience|Depression||Research Area|Neuroscience|Behavioral Neuroscience|Sleep & Biological Rhythms
Smiles: N1(CC2=CC=CC(C#CCCN3CCCCC3)=C2)CCOCC1
Inchikey: HDRIBIYPLKZUDQ-UHFFFAOYSA-N
Cas Number: 544707-20-2
Formulation: A crystalline solid
Storage Temp: -20
Shipping Temp: -20
Formula Markup: C20H28N2O • 2HCl
Formula Weight: 385.4
Shelf Life Days: 1460