mouse monoclonal IgG2b; SmcX Antibody (G-10) is an IgG2b κ mouse monoclonal SmcX antibody (also designated SmcX antibody) that detects the SmcX protein of mouse, rat and human origin by WB, IP, IF and ELISA. SmcX Antibody (G-10) is available as both the non-conjugated anti-SmcX antibody form, as well as multiple conjugated forms of anti-SmcX antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. SmcX, also known as JARID1C (jumonji, AT rich interactive domain 1C), MRXJ, KDM5C or XE169, is a nuclear protein that contains one ARID domain, one JmjC domain, one JmjN domain and two PHD-type zinc fingers and belongs to the JARID1 histone demethylase family. Expressed ubiquitously with highest expression in brain and skeletal muscle, SmcX functions as a histone demethylase that removes methyl groups from lysine residues on Histone H3, thereby playing a role in the histone code, as well as transcriptional regulation and chromatin remodeling. SmcX binds iron and α-ketoglutarate as cofactors and can recruit histone deacetylases to neuron silencer elements, thus repressing the transcription of neuronal genes. Defects in the gene encoding SmcX are associated with X-linked mental retardation (XLMR), a condition characterized by cognitive impairment and a low IQ. Multiple isoforms of SmcX are expressed due to alternative splicing events.

Free sample available. Limit 3 free samples for each full size Santa Cruz Biotechnology primary antibody ordered. All samples must be different. Customer responsible for shipping costs.