DESCRIPTION

• Notes: License Disclosure: Visit bpsbioscience.com/license for the label license and other key information about this product.  Troubleshooting Guide: Visit bpsbioscience.com/cell-line-faq for detailed troubleshooting instructions. For all further questions, please email support@bpsbioscience.com.
• Uniprot: P48546
• Shiptemp: -80°C (dry ice)
• Synonyms: Gastric inhibitory polypeptide receptor, GIP-R, Glucose-dependent insulinotropic polypeptide receptor, GIPR
• Warnings: Avoid freeze/thaw cycles
• Category: Cell Signaling/Cell Line
• Background: The gastric inhibitory polypeptide receptor (GIPR), also known as the glucose-dependent insulinotropic polypeptide receptor belongs to the Class B1 G protein-coupled receptor (GPCR) family. GIPR is primarily found in the β-cells of the pancreas and serves as a receptor for the gastric inhibitory polypeptide (GIP) hormone. As one of the incretin hormones, GIP modulates glucose metabolism by stimulating the pancreatic β-cells to release insulin. Since GIPR/GLP-1R heterodimerization has been shown to regulate GLP-1R signaling, dual agonists that bind both GIPR and GLP-1R have shown promising clinical efficacy for treating type II diabetes mellitus (T2DM) and obesity.  
• Description: Recombinant HEK293 cells expressing the firefly luciferase gene under the control of cAMP response element (CRE), and with forced expression of human GIPR (Gastric Inhibitory Polypeptide receptor; NM_000164.4). Activation of GIPR in these cells can be monitored by measuring luciferase activity. The functionality of the GIPR/CRE Luciferase Reporter HEK293 Cell Line was validated in a dose-response assay using agonists gastric inhibitory peptide (GIP) and tirzepatide hydrochloride. These agonists induce luciferase activity in a dose-dependent manner as depicted in Figure 1. Figure 1. Illustration of the GIPR/CRE Luciferase Reporter HEK293 Cell line.
• Supplied As: Each vial contains ~2 x 106 cells in 1 ml of cell freezing medium (BPS Bioscience, #79796)
• Unspsc Code: 41106514
• Unspsc Name: Stable mammalian cell lines
• Applications: Screen and characterize agonists of human GIPR in a cellular context
• Host Species: human
• Product Type: Cell Line
• Host Cell Line: HEK293, Human Embryonic Kidney, epithelial-like cells, adherent
• Biosafety Level: BSL-2
• Related Products: 60690, 79544, 60187, 78176
• Storage Stability: Cells are shipped in dry ice and should immediately be thawed or stored in liquid nitrogen upon receipt. Do not use a -80°C freezer for long term storage. 
• Mycoplasma Testing: The cell line has been screened to confirm the absence of Mycoplasma species.
• Scientific Category: Cell Signaling Pathway
• Required Accessories: 60187,79544,79796,60690
• Signed License Required: Yes