PVRL1 Antibody (C-term) Blocking Peptide

DETAILS

Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
Gene Id: 5818
Category: Peptides; Blocking Peptides
Subtitle: Synthetic peptide
Gene Name: NECTIN1
Other Names: Nectin-1, Herpes virus entry mediator C, Herpesvirus entry mediator C, HveC, Herpesvirus Ig-like receptor, HIgR, Poliovirus receptor-related protein 1, CD111, PVRL1, HVEC, PRR1
Availability: 2 weeks
Bio Background: This gene encodes an adhesion protein that plays a role inthe organization of adherens junctions and tight junctions inepithelial and endothelial cells. The protein is acalcium(2+)-independent cell-cell adhesion molecule that belongs tothe immunoglobulin superfamily and has 3 extracellularimmunoglobulin-like loops, a single transmembrane domain (in someisoforms), and a cytoplasmic region. This protein acts as areceptor for glycoprotein D (gD) of herpes simplex viruses 1 and 2(HSV-1, HSV-2), and pseudorabies virus (PRV) and mediates viralentry into epithelial and neuronal cells. Mutations in this genecause cleft lip and palate/ectodermal dysplasia 1 syndrome (CLPED1)as well as non-syndromic cleft lip with or without cleft palate(CL/P). Alternative splicing results in multiple transcriptvariants encoding proteins with distinct C-termini. [provided byRefSeq].
Bio References: Nikopensius, T., et al. Birth Defects Res. Part A Clin. Mol. Teratol. 88(9):748-756(2010)Vetter, G., et al. Oncogene 29(31):4436-4448(2010)Kim, J., et al. J. Biol. Chem. 285(30):22919-22926(2010)Jagomagi, T., et al. Eur. J. Oral Sci. 118(3):213-220(2010)Jugessur, A., et al. PLoS ONE 5 (7), E11493 (2010) :
Primary Accession: Q15223