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HY-15404

Darusentan

MedChem Express

- Open Babel Depiction O N H 3 C CH 3 HO O O N H 3 C O O

DESCRIPTION

Darusentan (Lu-135252) is a selective endothelin receptor A (ET-A) receptor antagonist, which binds with a Ki of 1.4 nM to the ET-A receptor and a Ki of 184 nM to ET-B receptor, respectively with a 100-fold selectivity for ETA rather than ETB receptors[1]. Darusentan competes for radiolabeled endothelin binding in rat aortic vascular smooth muscle cells (RAVSMs) membranes with single-site kinetics, exhibiting a Ki of 13 nM[2].

DETAILS

  • Purity: >98%
  • Smiles: COC1=NC(O[C@H](C(O)=O)C(C2=CC=CC=C2)(C3=CC=CC=C3)OC)=NC(OC)=C1
  • Category: Reference compound
  • Lead Time: 1-2 days
  • Cas Number: 171714-84-4
  • Molecular Weight: 410.42
  • Molecular Formula: C22H22N2O6

Lead Time: 1-2 days

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