PC9-M82E1-25ug PC9-M82E1-200ug
Biotinylated Mouse PCSK9 Protein, Avitag™,His Tag
ACROBiosystems
Image
![](https://www.acrobiosystems.com/static/main/products/images/sds/PC9-M82E1.jpg)
Image
![](https://www.acrobiosystems.com/static/main/products/images/elisa/PC9-M82E1-E1.jpg)
Image
![](https://www.acrobiosystems.com/static/main/products/images/elisa/PC9-M82E1-E2.jpg)
Image
![](https://www.acrobiosystems.com/static/main/products/images/elisa/PC9-M82E1-E1.jpg)
DESCRIPTION
Proprotein convertase subtilisin/kexin type 9 (PCSK9) is also known as NARC1 (neural apoptosis regulated convertase), is a newly identified subtilase belonging to the peptidase S8 subfamily. Mouse PCSK9 is synthesized as a soluble zymogen, and undergoes autocatalytic intramolecular processing in the endoplasmic reticulum, resulting in the cleavage of its propeptide that remains associated with the secreted active enzyme with a broad alkaline pH optimum. This protein plays a major regulatory role in cholesterol homeostasis. PCSK9 binds to the epidermal growth factor-like repeat A (EGF-A) domain of the low-density lipoprotein receptor (LDLR), inducing LDLR degradation. PCSK9 may also have a role in the differentiation of cortical neurons. Mutations in this gene have been associated with a rare form of autosomal dominant familial hypercholesterolemia (HCHOLA3).
DETAILS
- Tag: C-Avi & C-10×His
- Host: HEK293
- Size: 200ug
- Buffer: PBS, pH7.4
- Format: Powder
- Purity: 95%
- Source: MABSol® Biotinylated Mouse PCSK9, Avitag,His Tag (PC9-M82E1) is expressed from human HEK293 cells. It contains AA Gln 35 - Gln 694 (Accession # AAH38085.1).
- Storage: -20℃
- Category: MABSol® Biotin Labeled Proteins
- Molecule: PCSK9
- Accession: AAH38085.1
- Conjugate: Biotin-labeled
- Stability: ● -20°C to -70°C for 12 months in lyophilized state; ● -70°C for 3 months under sterile conditions after reconstitution. For long term storage, the product should be stored at lyophilized state at -20°C or lower.
- Exp Region: Gln 35 - Gln 694
- Swiss-prot: Q80W65
- Package Size: 200ug*1
- Characteristics: This protein carries an Avi tag (Avitag™) at the C-terminus, followed by a polyhistidine tag. This protein undergoes autocatalytic cleavage to release the pro-peptide and mature chain. The protein has a calculated MW of 13.9 kDa and 61.1 kDa. The protein migrates as 16 kDa and 66 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.
- Endotoxin Level: 1.0 EU per μg
- Molecular Weight: 13.9 kDa and 61.1 kDa
- Shipping Condition: RT
- Species Reactivity: Mouse
- Extra Shippinghandling Fee: Please see 'Shipping-and-Payments' sheet. Website: https://www.acrobiosystems.com/A48-Shipping-and-Payments.html