Cynomolgus Integrin alpha V beta 1 (ITGAV&ITGB1) Heterodimer Protein, His Tag&Tag Free

DESCRIPTION

Integrin alpha-5/beta-1 is a receptor for ibrinogen. Integrin alpha-1/beta-1, alpha-2/beta-1, alpha-6/beta-1 and alpha-7/beta-1 are receptors for lamimin. Integrin alpha-4/beta-1 is a receptor for VCAM1. It recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha-9/beta-1 is a receptor for VCAM1, cytotactin and osteopontin. It recognizes the sequence A-E-I-D-G-I-E-L in cytotactin. Integrin alpha-V/beta-1 is also a receptor for vitronectin. Beta-1 integrins recognize the sequence R-G-D in a wide array of ligands. Isoform 2 interferes with isoform 1 resulting in a dominant negative effect on cell adhesion and migration (in vitro). When associated with alpha-7/beta-1 integrin, regulates cell adhesion and laminin matrix deposition.

DETAILS

Tag: C-10×His | Native
Host: HEK293
Size: 1mg
Buffer: 50 mM Tris, 150 mM NaCl, pH 8.0
Format: Powder
Purity: 90%
Source: Cynomolgus Integrin alpha V beta 1 (ITGAV&ITGB1) Heterodimer Protein, His Tag&Tag Free (IT1-C52W4) is expressed from human 293 cells (HEK293). It contains AA Phe 31 - Pro 993 & Gln 161 - Asp 868 (Accession # A0A2K5WCD3-1 & A0A7N9D0D7).
Storage: -20℃
Category: Bio-Markers & CD Antigens
Molecule: Integrin alpha V beta 1
Conjugate: Unconjugated
Stability: ● -20°C to -70°C for 12 months in lyophilized state; ● -70°C for 3 months under sterile conditions after reconstitution. For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Exp Region: Phe 31 - Pro 993 & Gln 161 - Asp 868
Swiss-prot: A0A2K5WCD3-1 | A0A7N9D0D7
Package Size: 500ug*2
Characteristics: Cynomolgus Integrin alpha V beta 1 (ITGAV&ITGB1) Heterodimer Protein, His Tag&Tag Free, produced by co-expression of ITGAV and ITGB1, has a calculated MW of 113 kDa (ITGAV) and 83.6 kDa (ITGB1). The protein migrates as 80-100 kDa and 110-130 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under non-reducing (NR) condition (SDS-PAGE) due to glycosylation.
Endotoxin Level: 1.0 EU per μg
Molecular Weight: 113 kDa & 83.6 kDa
Shipping Condition: RT
Species Reactivity: Cynomolgus
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