6676296-25mg 6676296-10mg
BIO
Biogems
DESCRIPTION
BIO is a cell-permeable selective irreversible inhibitor of glycogen synthase kinase-3 (GSK-3). This inhibitory effect is reported to activate the Wnt signaling pathway and promote self-renewal in human and mouse cells. BIO is also useful in the differentiation of cardiomyocytes from human embryonic cells and Induced pluripotent stem cells as well as cellular reprogramming of mouse cell lines into iPS cells.
DETAILS
- Purity: ≥98%
- Synonyms: MLS001074886, SCHEMBL15565919, SMR000568408, 6BIO
- Cas Number: 667463-62-9
- References: Meijer, L., Skaltsounis, A. L., Magiatis, P., Polychronopoulos, P., Knockaert, M., Leost, M., ... & Greengard, P. (2003). GSK-3-selective inhibitors derived from Tyrian purple indirubins. Chemistry & biology, 10(12), 1255-1266. Tseng, A. S., Engel, F. B., & Keating, M. T. (2006). The GSK-3 inhibitor BIO promotes proliferation in mammalian cardiomyocytes. Chemistry & biology,13(9), 957-963. Sato, N., Meijer, L., Skaltsounis, L., Greengard, P., & Brivanlou, A. H. (2004). Maintenance of pluripotency in human and mouse embryonic stem cells through activation of Wnt signaling by a pharmacological GSK-3-specific inhibitor. Nature medicine, 10(1), 55-63.
- Application: FA
- Formulation: Crystalline solid
- Chemical Name: (3E)-6-bromo-3-[3-(hydroxyamino)indol-2-ylidene]-1H-indol-2-one
- Molecular Weight: 356.2
- Molecular Formula: C16H10BrN3O2
- Storage Conditions: Product should be kept at -20°C.
- Pubchem Openeye Can Smiles: C1=CC=C2C(=C1)C(=C(N2)C3=C(NC4=C3C=CC(=C4)Br)O)N=O