3661-MSM13-P0 3661-MSM13-P1 3661-MSM13-P1ABX
IRF3 - CloneID - PCRP-IRF3-3B2
NeoBiotechnologies
DESCRIPTION
Interferon regulatory factor-1 (IRF-1) and IRF-2 have been identified as novel DNA-binding factors that function as regulators of both type I interferon (interferon-伪and 尾) and interferon-inducible genes. The two factors are structurally related, particularly in their N-terminal regions, which confer DNA binding specificity. In addition, both bind to the same sequence within the promoters of interferon-伪and interferon-尾genes. IRF-1 functions as an activator of interferon transcription, while IRF-2 binds to the same cis elements and represses IRF-1 action. IRF-1 and IRF-2 have been reported to act in a mutually antagonistic manner in regulating cell growth; overexpression of the repressor IRF-2 leads to cell transformation while concomitant overexpression of IRF-1 causes reversion. IRF-1 and IRF-2 are members of a larger family of DNA binding proteins that includes IRF-3, IRF-4, IRF-5, IRF-6, IRF-7, ISGF-3纬p48 and IFN consensus sequence-binding protein (ICSBP).
DETAILS
- Host: Mouse
- Gene ID: 3661
- Uniprot: Q14653
- Clone ID: PCRP-IRF3-3B2
- Clonality: Monoclonal
- Gene Name: IRF3
- Supplied As: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
- Applications: WB, IF
- Protein Target: IRF3
- Species Reactivity: Human
- Storage Conditions: Antibody with azide - store at 2 to 8C. Antibody without azide - store at -20 to -80 C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.