Phospho-CASP3(S12) Antibody Blocking peptide

DETAILS

Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
Gene Id: 836
Category: Peptides; Blocking Peptides
Subtitle: Synthetic peptide
Gene Name: CASP3
Other Names: Caspase-3, CASP-3, Apopain, Cysteine protease CPP32, CPP-32, Protein Yama, SREBP cleavage activity 1, SCA-1, Caspase-3 subunit p17, Caspase-3 subunit p12, CASP3, CPP32
Availability: 2 weeks
Bio Background: This gene encodes a protein which is a member of thecysteine-aspartic acid protease (caspase) family. Sequentialactivation of caspases plays a central role in the execution-phaseof cell apoptosis. Caspases exist as inactive proenzymes whichundergo proteolytic processing at conserved aspartic residues toproduce two subunits, large and small, that dimerize to form theactive enzyme. This protein cleaves and activates caspases 6, 7 and9, and the protein itself is processed by caspases 8, 9 and 10. Itis the predominant caspase involved in the cleavage of amyloid-beta4A precursor protein, which is associated with neuronal death inAlzheimer's disease. Alternative splicing of this gene results intwo transcript variants that encode the same protein. [provided byRefSeq].
Bio References: Wurstle, M.L., et al. J. Biol. Chem. 285(43):33209-33218(2010)Srikanth, C.V., et al. Science 330(6002):390-393(2010)Burke, S.P., et al. J. Biol. Chem. 285(39):30061-30068(2010)Chen, W., et al. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 26(7):673-674(2010)Bellini, M.F., et al. Anticancer Res. 30(7):2845-2849(2010)
Primary Accession: P42574