TR2-C52H7-100ug TR2-C52H7-1mg
Cynomolgus TRAIL R2 / DR5 / TNFRSF10B Protein, His Tag (MALS verified)
ACROBiosystems
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DESCRIPTION
Tumor necrosis factor receptor superfamily member 10B (TNFRSF10B) is also known as TNF-related apoptosis-inducing ligand receptor 2 (TRAILR2), Death receptor 5 (DR5), CD262, KILLER, is a member of the TNF-receptor superfamily, and contains an intracellular death domain. TNFRSF10B / DR-5 is widely expressed in adult and fetal tissues; very highly expressed in tumor cell lines. TRAILR2 / CD262 / DR5 is the receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD (a death domain containing adaptor protein) of TRAIL-R2 / TNFRSF10B recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. CD262 / DR5 Promotes the activation of NF-kappa-B. DR5 is essential for ER stress-induced apoptosis and is regulated by p53/TP53.
DETAILS
- Tag: C-10×His
- Host: HEK293
- Size: 100ug
- Buffer: PBS, pH7.4
- Format: Powder
- Purity: 90%
- Source: Cynomolgus TRAIL R2, His Tag (TR2-C52H7) is expressed from human 293 cells (HEK293). It contains AA Ile 58 - Ser 212 (Accession # A0A2K5TXK0-1).
- Storage: -20℃
- Category: Bio-Markers & CD Antigens
- Molecule: TRAIL R2
- Conjugate: Unconjugated
- Stability: ● -20°C to -70°C for 12 months in lyophilized state; ● -70°C for 3 months under sterile conditions after reconstitution. For long term storage, the product should be stored at lyophilized state at -20°C or lower.
- Exp Region: Ile 58 - Ser 212
- Swiss-prot: A0A2K5TXK0-1
- Package Size: 100ug*1
- Characteristics: This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 19.1 kDa. The protein migrates as 25-30 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
- Endotoxin Level: 1.0 EU per μg
- Molecular Weight: 19.1 kDa
- Shipping Condition: RT
- Species Reactivity: Cynomolgus
- Extra Shippinghandling Fee: Please see 'Shipping-and-Payments' sheet. Website: https://www.acrobiosystems.com/A48-Shipping-and-Payments.html