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Recombinant Human sTNF Receptor Type I



TNFRI belongs to the TNFR superfamily of transmembrane proteins, and is expressed in most cell types. Binding of either TNF-alpha or TNF-beta to TNFRI initiates a signal transduction pathway that results in the activation of the transduction factor NF-kappaB, whose target genes are involved in the regulation of inflammatory responses, and, in certain cells induce apoptosis. Soluble TNF Receptor I (sTNFRI) is capable of inhibiting TNF-alpha and TNF-beta activities by acting as a decoy receptor that serves as a sink for the TNF ligands. The human TNFRI gene encodes for a 455 amino acid type I transmembrane protein, which contains a 21 amino acid signal sequence, a 190 amino acid extracellular domain, a 23 amino acid transmembrane domain, and a 221 amino acid cytoplasmic domain. Recombinant Human sTNF Receptor Type I is an 18.3 kDa protein (162 amino acid residues) comprising the cysteine-rich, ligand-binding portion of the extracellular domain of the TNFRI protein.


  • Gene Id: 7132
  • Uniprot: P19438
  • Activity: Determined by its inhibitory effect of the TNF-alpha mediated cytotoxicity in murine L-929 cells. The ED50 for this effect in the presence of 0.25 ng/ml of recombinant human TNF-alpha, is 0.05 ug/ml.
  • Category: RUO Cytokines
  • Subcategory: Growth Factors & Cytokines
  • Research Areas: Apoptosis, Immune System, Inflammation, Neurobiology, Receptors, Stem Cells and Differentiation, TNF Superfamily
  • Alternative Names: Soluble Tumor Necrosis Factor Type I, TNFRSF1A, TNFAR, TNFR60, p55, CD120a
  • Species of Origin: Human
  • Expression System Source: E.coli