T6301
Tosedostat
TargetMol
DETAILS
- Cas: 238750-77-1
- Purity: 99.4%
- Smiles: [C@@H](NC([C@@H]([C@@H](C(NO)=O)O)CC(C)C)=O)(C(OC1CCCC1)=O)C2=CC=CC=C2
- Category: Compound
- Molecular Weight: 406.47
- Molecular Formula: C21H30N2O6
DESCRIPTION
Tosedostat (CHR-2797) is an orally bioavailable inhibitor of the M1 family of aminopeptidases with potential antineoplastic activity. Tosedostat is converted intracellularly into a poorly membrane-permeable active metabolite (CHR-79888) which inhibits the M1 family of aminopeptidases, particularly puromycin-sensitive aminopeptidase (PuSA), and leukotriene A4 (LTA4) hydrolase; inhibition of these aminopeptidases in tumor cells may result in amino acid deprivation, inhibition of protein synthesis due to a decrease in the intracellular free amino acid pool, an increase in the level of the proapoptotic protein Noxa, and cell death.
Lead Time: 4 - 5 weeks
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