mouse monoclonal IgM; p-RELA/NFκB p65 Antibody (A-8) is an IgM κ mouse monoclonal p-NFκB p65 antibody (also designated p-NFκB p65 antibody or RELA, RelA, p65, NFKB3 antibody) that detects Ser 311 phosphorylated NFκB p65 of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA. p-RELA/NFκB p65 Antibody (A-8) is available as the non-conjugated anti-p-NFκB p65 antibody form. Proteins encoded by the v-Rel viral oncogene and its cellular homolog, c-Rel, are members of a family of transcription factors that include the two subunits of the transcription factor NFκB (p50 and p65) and the Drosophila maternal morphogen, dorsal. Both proteins specifically bind to DNA sequences that are the same or slight variations of the 10 bp κB sequence in the immunoglobulin κ light chain enhancer. This same sequence is also present in a number of other cellular and viral enhancers. The DNA binding activity of NFκB is activated and NFκB is subsequently transported from the cytoplasm to the nucleus in cells exposed to mitogens or growth factors. cDNAs encoding precursors for two distinct proteins have been described, designated p105 and p100. The p105 precursor contains p50 at its N-terminus and a C-terminal region that when expressed as a separate molecule, designated pdI, binds to p50 and regulates its activity.The NFκB transcription factor is a protein complex consisting of a DNA binding subunit and an associated protein. The DNA binding subunit, also referred to as Rel A, is functionally related to c-Rel p75 and RelB p68. NFκB p65 is phosphorylated at Serine-311 as a response to protein kinase C ζ.

Free sample available. Limit 3 free samples for each full size Santa Cruz Biotechnology primary antibody ordered. All samples must be different. Customer responsible for shipping costs.