mouse monoclonal IgG1; TRβ1 Antibody (A-7) is an IgG1 κ mouse monoclonal TRβ1 antibody that detects TRβ1 of mouse, rat and human origin by WB, IP, IF and ELISA. TRβ1 Antibody (A-7) is available as the non-conjugated anti-TRβ1 antibody form, as well as multiple conjugated forms of anti-TRβ1 antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. Thyroid hormone nuclear receptors (TRs) are ligand-dependent transcription factors which regulate growth, differentiation and development, and represent members of the steroid/retinoic acid superfamily. The two genes encoding TRs identified to date, TRα and TRβ, have been mapped to human chromosomes 17 and 3, respectively. TRs bind to thyroid hormone response elements (TREs) with half-site binding motifs in the orientation of palindromes, direct repeats or inverted palindromes. The affinities of binding are both variable and influenced differentially by 3,5,3′-triiodo-L-thyronine (T3). Transcriptional regulation by TRs is also modulated by heterodimerization with TR nuclear accessory proteins, the most extensively characterized of which are the retinoid X receptors (RXRα, RXRβ and RXRγ). The TRβ isoform TRβ1 forms a complex with the PI 3-kinase p85α subunit and plays an important role in the T3-induced activation of Akt in pancreatic β cells.

Free sample available. Limit 3 free samples for each full size Santa Cruz Biotechnology primary antibody ordered. All samples must be different. Customer responsible for shipping costs.