mouse monoclonal IgG2b; TRIM66 Antibody (A-9) is an IgG2b κ mouse monoclonal TRIM66 antibody that detects the TRIM66 protein of mouse, rat and human origin by WB, IP, IF and ELISA. TRIM66 Antibody (A-9) is available as both the non-conjugated anti-TRIM66 antibody form, as well as multiple conjugated forms of anti-TRIM66 antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. The tripartite motif (TRIM) family of proteins are characterized by a conserved TRIM domain that includes a coiled-coil region, a B-box type zinc finger, one RING finger and three zinc-binding domains. TRIM proteins are involved in a wide variety of cellular processes such as cell development, proliferation, differentiation, oncogenesis and apoptosis. TRIM66 (tripartite motif-containing protein 66), also known as TIF1D, C11orf29 or KIAA0298, is a 1,216 amino acid protein belonging to the TRIM family, and contains two B box-type zinc fingers, one bromo domain, and one PHD-type zinc finger. Localizing to nucleus, TRIM66 is strongly expressed in testis, thymus, and kidney, with moderate expression in prostate and ovary. TRIM66 may form individual foci in the centrometric chromocenter and the surrounding nucleoplasm, and may also function as a transcription repressor, mediated by recruitment of deacetylase activity, and as a negative regulator of postmelotic genes. Existing as two alternatively spliced isoforms, the gene encoding TRIM66 maps to human chromosome 11p15.4.

Free sample available. Limit 3 free samples for each full size Santa Cruz Biotechnology primary antibody ordered. All samples must be different. Customer responsible for shipping costs.