Human FUS Protein, His Tag

DESCRIPTION

FUS (RNA-binding protein FUS) is a DNA/RNA-binding protein that plays a role in various cellular processes such as transcription regulation, RNA splicing, RNA transport, DNA repair and damage response. It binds to nascent pre-mRNAs and acts as a molecular mediator between RNA polymerase II and U1 small nuclear ribonucleoprotein thereby coupling transcription and splicing. It binds also its own pre-mRNA and autoregulates its expression; this autoregulation mechanism is mediated by non-sense-mediated decay. FUS plays a role in DNA repair mechanisms by promoting D-loop formation and homologous recombination during DNA double-strand break repair. In neuronal cells, FUS plays crucial roles in dendritic spine formation and stability, RNA transport, mRNA stability and synaptic homeostasis.

DETAILS

Tag: N-10×His
Host: E. coli
Size: 100ug
Buffer: PBS, pH7.4
Format: Powder
Purity: 85%
Source: Human FUS Protein, His Tag (FUS-H5144) is expressed from E. coli cells. It contains AA Met 1 - Tyr 526 (Accession # P35637-1).
Storage: -20℃
Category: Other Recombinant Proteins
Molecule: FUS
Conjugate: Unconjugated
Stability: ● -20°C to -70°C for 12 months in lyophilized state; ● -70°C for 3 months under sterile conditions after reconstitution. For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Exp Region: Met 1 - Tyr 526
Swiss-prot: P35637
Package Size: 100ug*1
Characteristics: This protein carries a polyhistidine tag at the N-terminus. The protein has a calculated MW of 97.0 kDa. The protein migrates as 95 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE).
Endotoxin Level: 1.0 EU per μg
Molecular Weight: 97.0 kDa
Shipping Condition: RT
Species Reactivity: Human
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