BAX Blocking Peptide (N-term)

DETAILS

Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
Gene Id: 581
Category: Peptides; Blocking Peptides
Subtitle: Synthetic peptide
Gene Name: BAX
Other Names: Apoptosis regulator BAX, Bcl-2-like protein 4, Bcl2-L-4, BAX, BCL2L4
Availability: 2 weeks
Bio Background: Accelerates programmed cell death by binding to, and antagonizing the apoptosis repressor BCL2 or its adenovirus homolog E1B 19k protein. Under stress conditions, undergoes a conformation change that causes translocation to the mitochondrion membrane, leading to the release of cytochrome c that then triggers apoptosis. Promotes activation of CASP3, and thereby apoptosis.
Bio References: Oltvai Z.N.,et al.Cell 74:609-619(1993). Apte S.S.,et al.Genomics 26:592-594(1995). Shi B.,et al.Biochem. Biophys. Res. Commun. 254:779-785(1999). Schmitt E.,et al.Biochem. Biophys. Res. Commun. 270:868-879(2000). Cartron P.F.,et al.Hum. Mol. Genet. 11:675-687(2002).
Primary Accession: Q07812
Targetspecificity: The synthetic peptide sequence is selected from aa 47-58 of HUMAN BAX