• Purity: ≥98%
• Synonyms: U-0126, UO-126
• Cas Number: 109511-58-2
• References: Duncia, J. V., Santella, J. B., Higley, C. A., Pitts, W. J., Wityak, J., Frietze, W. E., ... & Teleha, C. A. (1998). MEK inhibitors: the chemistry and biological activity of U0126, its analogs, and cyclization products. Bioorganic & medicinal chemistry letters, 8(20), 2839-2844. Satoh, T., Nakatsuka, D., Watanabe, Y., Nagata, I., Kikuchi, H., & Namura, S. (2000). Neuroprotection by MAPK/ERK kinase inhibition with U0126 against oxidative stress in a mouse neuronal cell line and rat primary cultured cortical neurons. Neuroscience letters, 288(2), 163-166. Hotokezaka, H., Sakai, E., Kanaoka, K., Saito, K., Matsuo, K. I., Kitaura, H., ... & Nakayama, K. (2002). U0126 and PD98059, specific inhibitors of MEK, accelerate differentiation of RAW264. 7 cells into osteoclast-like cells.Journal of Biological Chemistry, 277(49), 47366-47372. Ge, X., Fu, Y. M., & Meadows, G. G. (2002). U0126, a mitogen-activated protein kinase kinase inhibitor, inhibits the invasion of human A375 melanoma cells. Cancer letters, 179(2), 133-140.
• Application: FA
• Formulation: Crystalline solid
• Chemical Name: (2Z,3Z)-2,3-bis[amino-(2-aminophenyl)sulfanylmethylidene]butanedinitrile
• Molecular Weight: 380.5
• Molecular Formula: C18H16N6S2
• Storage Conditions: Product should be kept at -20°C.
• Pubchem Openeye Can Smiles: C1=CC=C(C(=C1)N)SC(=C(C#N)C(=C(N)SC2=CC=CC=C2N)C#N)N

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