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Recombinant Rat IL-13 (109 a.a.)



IL-13 is an immunoregulatory cytokine produced primarily by activated Th2 cells, and also by mast cells and NK cells. Targeted deletion of IL-13 in mice resulted in impaired Th2 cell development and indicated an important role for IL-13 in the expulsion of gastrointestinal parasites. IL-13 exerts anti-inflammatory effects on monocytes and macrophages and it inhibits the expression of inflammatory cytokines such as IL-1beta, TNF-alpha, IL-6 and IL-8. IL-13 has also been shown to enhance B cell proliferation and to induce isotype switching, resulting in increased production of IgE. Blocking of IL-13 activity inhibits the pathophysiology of asthma. Human and murine IL-13 are cross-species reactive. Recombinant Rat IL-13 is an 11.9 kDa protein consisting of 109 amino acid residues.


  • Gene Id: 116553
  • Uniprot: P42203
  • Activity: The ED50 as determined by the dose-dependant stimulation of the proliferation of human TF-1 cells is ≤ 40 ng/ml, corresponding to a specific activity of ≥ 2.5 x 10^4 units/mg.
  • Category: RUO Cytokines
  • Subcategory: Growth Factors & Cytokines
  • Research Areas: AIDS/HIV, Cancer, Immune System, Inflammation, Stem Cells and Differentiation, Allergy, COVID-19
  • Alternative Names: NC300 (Human), P600 (Murine)
  • Species of Origin: Rat
  • Expression System Source: E.coli