DESCRIPTION

• Shiptemp: -80°C (dry ice)
• Synonyms: Stromelysin-3 kit, SL-3 kit, SL3 kit, matrix metalloproteinase 11 kit, SARS CoV 2, sarscov2, Sars-Cov-2
• Warnings: Avoid freeze/thaw cycles.
• Category: Protease/Assay Kit
• Background: MMP11 (matrix metalloproteinase 11), also known as Stromelysin-3 (SL-3), is a member of the matrix metalloproteinase (MMP) family involved in the degradation of the extracellular matrix. MMP11 was initially discovered in breast carcinoma and has since been identified in diverse carcinomas and developmental processes. MMP-11 promotes cancer development by inhibiting apoptosis as well as enhancing migration and invasion of cancer cells. MMP11 is activated by furin, an enzyme linked to the entry of the SARS-CoV-2 virus into cells.
• References: 1. Peruzzi, Daniela, et al. 2009. "MMP11: a novel target antigen for cancer immunotherapy." Clinical Cancer Research 15(12): 4104-4113.2. Cheng, Chun-Wen, et al. 2010. "The clinical implications of MMP-11 and CK-20 expression in human breast cancer." Clinica Chimica Acta 411(3-4): 234-241.
• Description: The Fluorogenic MMP11 Assay Kit is designed to measure MMP11 activity for screening and profiling applications, in a homogeneous assay with no time-consuming washing steps. 
• Methodology: Fluorogenic
• Supplied As: The kit comes in a convenient 96-well format, with purified MMP11 enzyme, fluorogenic substrate, and MMP assay buffer for 100 enzyme reactions.
• Unspsc Code: 41105331
• Unspsc Name: Protein chemifluorescent detection reagents or kits or substrates
• Applications: Great for studying enzyme kinetics and HTS applications.
• Product Type: Assay Kit
• Biosafety Level: Not applicable (BSL-1)
• Related Products: 79918, 79991, 79993, 78017
• Storage Stability: At least one year from date of receipt when stored as directed.
• Scientific Category: Protease
• Instructions for Use: See assay protocol for detailed instructions.